Rescued as a child by the legendary assassin Moody, Anna (Maggie Q) is the world's most skilled contract killer. However, when Moody (Samuel L. Jackson) is brutally killed, she vows revenge for the man who taught her everything she knows. As Anna becomes entangled with an enigmatic killer called Rembrandt (Michael Keaton), their confrontation turns deadly, and the loose ends of a life spent killing weave themselves ever tighter.